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Thakur, Teena; Xavier, Janet R.; Cross, Lauren; Jaiswal, Manish K.; Mondragon, Eli; Kaunas, Roland; Gaharwar, Akhilesh K. (, Journal of Biomedical Materials Research Part A)
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Xavier, Janet R.; Thakur, Teena; Desai, Prachi; Jaiswal, Manish K.; Sears, Nick; Cosgriff-Hernandez, Elizabeth; Kaunas, Roland; Gaharwar, Akhilesh K. (, ACS Nano)
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Arun Kumar, Shreedevi; Balasubramaniam, Bhuvaneshwari; Bhunia, Sukanya; Jaiswal, Manish K.; Verma, Kartikey; Prateek; Khademhosseini, Ali; Gupta, Raju Kumar; Gaharwar, Akhilesh K. (, WIREs Nanomedicine and Nanobiotechnology)Abstract Two‐dimensional (2D) metal organic frameworks (MOFs), are an emerging class of layered nanomaterials with well‐defined structure and modular composition. The unique pore structure, high flexibility, tunability, and ability to introduce desired functionality within the structural framework, have led to potential use of MOFs in biomedical applications. This article critically reviews the application of 2D MOFs for therapeutic delivery, tissue engineering, bioimaging, and biosensing. Further, discussion on the challenges and strategies in next generation of 2D MOFs are also included. This article is categorized under:Nanotechnology Approaches to Biology > Nanoscale Systems in Biologymore » « less
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Desai, Prachi; Venkataramanan, Anjana; Schneider, Rebecca; Jaiswal, Manish K.; Carrow, James K.; Purwada, Alberto; Singh, Ankur; Gaharwar, Akhilesh K. (, Journal of Biomedical Materials Research Part A)Abstract Nanoparticle shape has emerged as a key regulator of nanoparticle transport across physiological barriers, intracellular uptake, and biodistribution. We report a facile approach to synthesize ellipsoidal nanoparticles through self‐assembly of poly(glycerol sebacate)‐co‐poly(ethylene glycol) (PGS‐co‐PEG). The PGS‐PEG nanoparticle system is highly tunable, and the semiaxis length of the nanoparticles can be modulated by changing PGS‐PEG molar ratio and incorporating therapeutics. As both PGS and PEG are highly biocompatible, the PGS‐co‐PEG nanoparticles show high hemo‐, immuno‐, and cytocompatibility. Our data suggest that PGS‐co‐PEG nanoparticles have the potential for use in a wide range of biomedical applications including regenerative medicine, stem cell engineering, immune modulation, and cancer therapeutics. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2048–2058, 2018.more » « less
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